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Edaravone and its clinical development for amyotrophic lateral sclerosis
In line with these findings, genes encoding for cystine transport (Slc7a11) and enzymes of the GSH biosynthetic pathway (GSS and GCL), are significantly upregulated in HLRCC patients (Supplementary Fig
In neurodegenerative diseases, SQOR dysfunction is linked to toxic H 2 S accumulation and neuroinflammation, and SQOR gene mutations can directly cause fatal Leigh syndrome (Gheibi et al., 2014
[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Bellot G., Garcia-Medina R., Gounon P., Chiche J., Roux D., Pouyssegur J., Mazure N.M
