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Botox does this by entering the nerve endings and cleaving a specific protein called SNAP25

This can be due to the absence of a tyrosine residue at the corresponding position (Y2518 in SMRT or Y1 in CTD) that interacts with SHARP R3566 via - interactions and forms hydrophobic contacts with M3553

Conversely, individuals with epilepsy also had a higher risk of developing depression (aHR = 1.88, 95% CI: 1.821.95)

doi: 10.1016/j.psyneuen.2018.10.026
