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doi: 10.1111/jne.12255

In vitro study found that topiramate increased MDA, NO and ROS production in astrocytes, showing a dose-dependent negative effect (Pavone and Cardile, 2003)

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Chittepu V., Kalhotra P., Osorio-Gallardo T., Gallardo-Velazquez T., Osorio-Revilla G

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FIGURE 1 5 SAW and mitochondrial dysfunction SAW is primarily characterized by skeletal muscle atrophy and weakness, often affecting skeletal and respiratory muscles, and in severe cases, it can lead to quadriplegia (Schefold et al., 2010)