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Although the C-terminus does not contain metal binding domains, which reside in its N-terminus, and is not known to participate in metalation of cuproenzymes (Yu, Dolgova & Dmitriev, 2017), more recent research has demonstrated that the carboxyl half of the protein is critical for anterograde and retrograde trafficking of ATP7A through its interaction with adaptor protein (AP) complexes 1 and 2 (Yi & Kaler, 2015)which play important roles in the regulation of intracellular vesicle trafficking (Robinson, 2004)

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Following a heavy metal detox plan is one of the best ways to start reversing symptoms