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Studies have found that under hypoxic conditions, HIF1 induced STAT3 via JAK or adenylate receptor 2B pathway, which upregulates the IL-6 and NANOG to maintain the CSC phenotype and also enhances the production of VEGF, required for the self-renewal ability of CSCs (79)

doi: 10.1183/13993003.00407-2016 99

[DOI] [PubMed] [Google Scholar] 172.Zhang Y.-J., Wang W., Yang H.-L., Li Y., Kang X.-Y., Wang X.-R., Yang Z.-L