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xiii Kidney Function : Drinking more than two drinks per day containing aspartame is associated with a decline in kidney function

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Based on these and other findings, we have previously proposed that MDD may be associated with dysregulation of afferent warm signals from distal cutaneous sensors to the central nervous system, i.e., involving heat-defense mechanisms traveling along the spinoparabrachial pathway 32 , leading secondarily to decreases in sweating as assessed by measurement of skin conductance levels 12,33,34,35,36

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