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While these studies illustrate the potential of omics to connect microbiome dynamics with host health in other epithelia, gaps remain in understanding skin microbiomecell interactions

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The substratereceptor complex is internalized by endosomes via the clathrin-dependent pathway, followed by lysosomal hydrolysis, where the lipid is dissociated from the complex due to a low pH, and the receptor is recycled back to the cell surface [156,157]