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Chemopreventive effects of dietary folate on intestinal polyps in apc+/-msh2-/- mice

Nuclear sclerotic cataracts are one of the most common types of age-related cataracts, which occur when the central portion of the eyes natural lens known as the nucleus becomes hardened (sclerotic) and increasingly cloudy over time

The slight but significant effect on periosteal and appendicular skeletal growth could be seen at a much earlier postnatal age (about 23 weeks) in mice having a liver-specific double knockout of igf-1 and the ALS that display a 90% reduction in serum IGF-1 levels