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BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming

FOXO4-DRIs D-retro-inverso configuration provides exceptional proteolytic stability compared to equivalent L-amino acid senolytic peptides a critical property for cell-based and pre-clinical research where intracellular peptidase activity would rapidly degrade unstable L-amino acid sequences

However, it is important to keep in mind that CLE visualizes a basolateral (subepithelial) to apical (luminal) flux of a small molecule (fluorescein) of which the correlation to luminal to subepithelial passage of luminal compounds, which is hypothesized to trigger a mucosal immune response and symptoms, is still unclear

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