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Additionally, high expression rate of nuclear NF-B p65 in FISS and dose-dependent inhibitory effects on the growth of FISS primary cells treated with NF-B inhibitors suggested a role of NF-B in FISS development (Hsueh et al., 2019)

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GLP-1 Receptor Agonists Glucagon-like peptide-1 receptor agonists were developed to treat type 2 diabetes and turned out to produce substantial weight loss

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Phase 1: Establish tirzepatide baseline (weeks 1-4) Start tirzepatide alone at 2.5mg weekly