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Another challenge for nose-to-brain drug delivery is the development of appropriate delivery devices, since standard devices are optimized for local effects and therefore deliver only a small amount of drug to the olfactory region [65]

3.2 Destruction of periodontal soft tissues The integrity and function of PDLFs, essential for softtissue homeostasis, are compromised by ferroptosis through a twofold assault on collagen: synthesis is reduced because PDLF viability and activity are impaired, while degradation is accelerated by ferroptosisassociated ROS and proinflammatory mediators ( in vitro primary cell models, indicate that ferroptosis in periodontal ligament fibroblasts serves as an active driver of soft tissue destruction

Proliferation and growth of DSMTs are closely linked to various Gln transporters

Therefore, prior studies have generally suggested that increased FUS-PrLD phosphorylation diminishes aggregation and toxicity 64,82,83

This intrinsic plasticity of biological systems is recognized as a limitation to sustained openloop stimulation