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(2023) employed response surface methodology (RSM) integrated with genetic algorithmartificial neural network (GAANN) modeling, identifying optimal conditions as follows: 52 C, 1:30 solidliquid ratio (w/v), 167 min duration, and 0.01 mol/L NaOH, yielding 29.53% BSP recovery

V max, approximately 0.5 nM/min per mg of protein) stimulated by ATP and a lower affinity component

perceptible and visible change, with less than 50% lightening of skin color) = marked improvement or remarkable change or improvement (whitening

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The addicted person feels an inner compulsion to increase doses of psychoactive substances, losing control over their use