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As a second choice, experts have agreed on the association of antiepileptics and antidepressants, while they disagree with the use of opioids

TawakolAIshaiATakxRAPFigueroaALAliAKaiserYet alRelation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study

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A randomized double-blind placebo-controlled trial demonstrated that 12 weeks of coenzyme Q10 supplementation can lower serum insulin levels in patients with PCOS (50)

A block in MMUT activity leads to accumulation of methylmalonic acid and other propionyl-CoA derived catabolites, which in turn have secondary effects on associated pathways and play a major role in the pathogenesis of MMA (3)