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PD patients often exhibit gut dysbiosis, characterized by an increase in Akkermansia and decreases in Faecalibacterium and Roseburia [33]
An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins

Zeng XL, Xie P, Fan J, Zhang B

To conclude, the activation mechanism of IRE-1, which senses fluctuation at the ER membrane, is distinct from the activation mechanism of proteotoxic stress
In vitro , co-administration of CBD and THC resulted in an additive neuroprotection of mouse hippocampal nerve cells (HT22 cells) against glutamate toxicity, while co-administration with both THC and CBN resulted in synergistic neuroprotection that was greater than a purely additive effect of the individual isolates (Schubert et al., 2019)
