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PMID: 26752456

Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]

It serves as a hub molecule that connects antioxidant defense, detoxification, immune signaling, and cellular metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Halliwell B

Furthermore, heightened levels of lipid peroxidation markers and diminished antioxidant capacity have been discerned in the brains of individuals afflicted with neurodegenerative diseases [469, 470], suggesting a potential role of ferroptosis in the selective neuronal loss (Tables 5 & 6)