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Generally, high ROS occur in GC cells due to H

Bioactive substances such as mahanine, mahanimbine, murrayanol, koenigicine, quercetin, apigenin, kaempferol, catechin, and oliolide in curry leaves have been reported to synergistically regenerate -cells, aid diabetic complications, and possess antihyperlipidemic effects [430,431]

13 Insights into the mechanisms of drug action started to change with the discovery of the intracellular signaling pathways regulated by receptors

Another study reported that Vitamin E ameliorated alterations to the cartilage of knee joints induced by monoiodoacetate and diabetes mellitus in rats, which manifested as inhibition of biomarkers of inflammation [164]

By Michael Dilluvio18 Aug 2025Medically reviewed by Dr