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Paeoniflorin also inhibits neuroinflammation and improves BIPN by decreasing IL-6 levels and modulating PARKIN-mediated mitochondrial autophagy (Sun et al., 2022)
Reported side effects are generally mild and may include nausea, dizziness, headache, or injection site irritation
It also may explain why KPV appears to have a favorable safety profile compared to more aggressive immunosuppressive approaches
Stadtman ER, Levine RL
