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After opening and / or dilution and / or reconstitution: the product should be used immediately

Purging typically resolves, with improvement following

This therapy has shown limited efficacy, with survival benefits ranging from weeks to several months (165), which may be related to the fact that tumors can activate alternative pathways of angiogenesis, increase invasiveness and metastasis, or develop resistance to anti-angiogenic therapy by immune system inhibition (166)

In such scenarios, implementing a control strategy to restore M2 macrophage concentrations to their equilibrium levels is desirable