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In contrast to findings in the APPROACH and COMPASS trials, volanesorsen or olezarsen ASO treatment did not significantly alter plasma LDL-cholesterol concentration in patients with mild-to-moderate HTG [81, 88]

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Although effects of BAs on CDI pathogenesis have been previously examined, 6,7,8,25 this is the first study to comprehensively examine the role of obesity-associated changes in gut BA metabolome in regulating CDI severity

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