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elegans with their own natural thiol, GSH, also shortened their lifespan (Fig

Beyond protein-level regulation, intracellular iron content is finely tuned at the transcriptional level via the iron-responsive element/iron regulatory protein (IREIRP) system (39)

Currently, the NRF2-regulated antioxidant system is emerging as a critical player in the context of OSA, becoming dysregulated due to IH and elevated levels of ROS

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In normal physiologic state, the brain parenchyma is only subject to nascent immune surveillance, however during inflammation, the elevated pro-inflammatory markers induce the increased expression of adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells of the BBB (Varatharaj and Galea, 2017