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Description
The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep

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the maximum total daily dose is 4g (2-3g/d for patients with hepatic insufficiency and/or a history of chronic alcohol use)

The following general discussion applies mainly to the rat

Chronic ethanol feeding Male mice (1012 wk old) were fed a modified Lieber-DeCarli (LD) diet (F4473SP and F4474SP
