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What endpoint markers should be measured to verify that stacking MOTS-c 5-Amino-1MQ is producing the expected metabolic effects

L., Schreiner, A., Dewson, G

A previous study reported that -KG, the metabolite of Glu, is more abundant in Th17 cells than in Treg cells, suggesting that glutaminolysis may be more active in Th17 cells (47).Further mechanistic findings revealed that 2-hydroxyglutarate (2-HG), a direct product of error-prone dehydrogenase activity on -KG, could trigger hypermethylation of the Foxp3 gene and inhibit Foxp3 transcription, thereby inhibiting the differentiation of Treg cells and regulating Th17/Treg homeostasis through epigenetic mechanisms ( Figure 2 ) (48)

Among DNMTs, the de novo methyltransferases DNMT3A and DNMT3B establish methylation patterns on unmethylated DNA through embryonic development (Figure 1) (Smallwood et al., 2011)

Clinical studies are underway to test this hypothesis and possible hormonal treatment options