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Notably, the oncogenic drivers prevalent in PDAC, such as mutant KRAS and loss of TP53 or SMAD4, intricately modulate key ferroptotic pathways, including the System Xc/GSH/GPX4 axis, the FSP1-CoQH system, and lipid metabolism networks, thereby dictating cellular susceptibility to ferroptotic stress

This enzyme converts oxidized glutathione into its reduced form

Untersttzt die zellulre Entgiftung und den antioxidativen Schutz

DOI: Nagane M, Kanai E, Shibata Y, Shimizu T, Yoshioka C, Maruo T, et al

Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet