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Furthermore, SF treatment showed promising effects on mitochondrial function in that there was improvement in mitochondrial parameters such as ATP-Linked Respiration and Proton Leak Respiration in the SF group compared to the placebo group

Such a trial would directly test whether correcting maternal deficiency can reduce ASD incidence or severity, addressing the inconclusive results of prior trials by focusing on deficient populations and possibly intervening earlier in gestation

Nasal Spray: Emerging in 2025 as a potential rapid-delivery research method for localized CNS or vascular endpoints, though formulation standardization remains variable

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