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The relevance of GMP activity is also indirectly witnessed by the presence of specific regulators interacting with the enzyme (Sawake et al., 2015)
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Moreover, given that melatonin is a well-known inhibitor of A in the AD brain (190, 191), it is proposed that it would similarly inhibit A formation in RPE cells and thereby alter AMD pathogenesis
10.1523/JNEUROSCI.1083-08.2008 [DOI] [PMC free article] [PubMed] [Google Scholar] Gaudet A
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