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doi: 10.1016/j.biopha.2020.110686 42 MatsushimaG

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137 By disrupting feedforward loops of cytokine-driven excitability, regulating myostatins atrophic signals, balancing ROS generation with MnSOD-mediated detoxification, and reactivating muscle fibers through NMES and specific exercise regimens, rehabilitation strategies can normalize sensorimotor function, reduce AMI, and protect against the long-term consequences of persistent quadriceps weakness and joint instability (Table 1)

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However, some natural compounds, such as 8 alkaloids [berberine hydrochloride (Zhu et al., 2019a), berberrubine (Yu et al., 2018), coptisine (Wang et al., 2021a), dihydroberberine (Li et al., 2021), evodiamine (Shen et al., 2019), matrine (Yan et al., 2020), nigakinone (Liu et al., 2023), and piperine (Qu et al., 2021), licochalcone A (Zhang et al., 2021), licoflavone B (Zhang et al., 2022b), phloretin (Zhang Z