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Segade F, Trask BC, Broekelmann TJ, Pierce RA, Mecham RP

When the transport of dopamine into synaptic vesicles is obstructed or VMAT2 is inhibited by drugs such as tetrabenazine and reserpine, excessive dopamine can accumulate in the cytoplasm, leading to the auto-oxidation of dopamine and the formation of harmful by-products, eventually leading to neurodegeneration

Mitochondrial-targeted therapies such as CoQ10, alpha-lipoic acid (ALA), and carnitine have been investigated for their role in improving ATP production, reducing oxidative stress, and enhancing cellular metabolism

Elevated RDW is most commonly seen in conditions with mixed populations of erythrocytes due to ineffective erythropoiesis, increased red cell turnover, or recent reticulocytosis, and is associated with conditions such as iron deficiency anemia, hemolytic anemia, and various chronic diseases

Caligiuri MA