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Moreover, combining active targeting with stimuli-responsive release mechanisms such as pH or ROS-sensitive adapters can enable specific release of CeT in the acidic or oxidative environment of tumors, thereby optimizing efficacy and minimizing side effects (Fig 3)

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However, further research is needed to understand the full extent of these effects and to identify any confounding factors

[DOI] [PMC free article] [PubMed] [Google Scholar] Li S.J., Qin W.X., Peng D.J., Yuan Z.X., He S.N., Luo Y.N., Aschner M., Jiang Y.M., Liang D.Y., Xie B.Y., Xu F

Nitrofurantoin (NFT) demonstrated Nrf2 activation and glutathione synthesis stimulation comparable to the potent experimental Nrf2 activator diethyl maleate