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Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges

Complementing this, Wu et al., 2019 studied AgNPs of various diameters (3.2, 20.7, 54.7, and 93.6 nm) in B16 mouse melanoma cells and found that nanoparticle size not only affected uptake efficiency but also dictated the endocytic pathways involved

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This reduction in SCFAs may play a crucial role in the ENS changes and gut dysmotility seen in PD