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Description
Sorafenib induces ferroptosis by targeting the cystine/glutamate anti-transport system Xc- [154,155,156,157], an effect that impinges on cystine uptake, thereby preventing subsequent synthesis of glutathione (GSH), the major intracellular antioxidant, preventing GPX4 activation [158, 159], and can trigger ER stress and ferroptosis
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A thorough medical screening by a qualified professional is essential to identify these risks
