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Das Risiko steigt zum einen durch die Kombination mit Monoaminoxidase(MAO-)Hemmern (Beispiel: Moclobemid), SNRI-Antidepressiva (Beispiel: Venlafaxin) und anderen serotonergen Substanzen (Beispiel: Tramadol), zum anderen aufgrund eines Plasmaspiegelanstiegs der SSRI durch abbauhemmende Modulatoren

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Route Topical / transdermal Published Dose Context Marketed by some clinics and compounders, but no published human exposure data was identified in FDA's December 2024 evaluation