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Upon binding, IGF-1R activates two downstream pathways: the PI3K/Akt pathway (driving protein synthesis and glucose uptake) and the MAPK/ERK pathway (promoting cell proliferation and differentiation)

2008;57 Suppl 1:S135-S141

This can harm cells and body capacities

Meyers S, Janowitz HD

Additionally, among the areas requiring further exploration is the long-term effect of the ketogenic diet (although it is already a relatively well-studied nutritional model, as it has been used since 1921)
