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Data availability The datasets generated and analyzed during the current study, along with the Stata analysis scripts, are openly available in the Figshare repository at [ Abbreviations BMI: Body mass index CI: Confidence interval CVD: Cardiovascular disease GRADE: Grading of Recommendations Assessment, Development and Evaluation HDL-C: High-density lipoprotein cholesterol KD: Ketogenic diet LDL-C: Low-density lipoprotein cholesterol MCID: Minimal clinically important difference NAFLD: Non-alcoholic fatty liver disease PCOS: Polycystic ovary syndrome PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses RCT: Randomized controlled trial REML: Restricted maximum likelihood RoB 2: Risk of Bias 2 (Cochrane tool) SD: Standard deviation SEM: Standard error of the mean TC: Total cholesterol TG: Triglycerides T2DM: Type 2 diabetes mellitus VLCKD: Very-low-carbohydrate ketogenic diet WMD: Weighted mean difference References Zhu H, et al

Rayman MP (2019) Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease

Hashimoto, K., Matsumoto, S., Yamada, M., Satoh, T

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