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Clinical features of liver cirrhosis patients with muscle cramping: a multicenter study

An early study reported that the activation of the MAPK signaling pathway could inhibit glioma cell growth and induce cell death, amplifying the antitumor effects of metformin (41)

Indeed, despite the limitation of a relatively small number of patients under investigation, that did not allow for multivariable analysis of parameters associated with graft outcome, our study was able to expand existing knowledge on the clinical role of GSTT1 Abs through a longitudinal evaluation of serum antibody dynamics, coupled with a parallel investigation at intragraft level

the published evidence base sits in animal models, cell culture, and small preclinical studies