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10.1038/nm1166 5 CaoR.WangH.WuW.TanZ.XiaoX.WuL.et al (2014)

144 Moreover, H 2 O 2 enhances proteasome activity via S-glutathionylation of cysteine residues in the 20S subunit

Performance indicators of degraded tirzepatide Visual inspection catches advanced degradation, but performance changes reveal earlier stages

Thus, triptolide derivatives can overcome the solubility and cytotoxicity limitations of the parent compound, enhancing bioavailability, targeting specificity, and reducing toxicity, while also providing innovative therapeutic modalities such as photodynamic therapy and optical imaging capabilities for improved cancer treatment outcomes

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