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The rivastigmine-loaded NLC was optimized using a three-factor three-level Box-Behnken design with three independent variables, sonication time, solid/lipid ratio (%), and emulsifier concentration (%) on dependent responses mean particle size and EE

doi:10.1186/s13048-015-0205-8

The decreased cholesterol level together with the increased phospholipid-to-bile acid ratio after Hitrechol treatment is considered to lower the chances of cholesterol precipitation and subsequent gallstone formation

These include preferential distribution and retention within specific tissues, the biological activity of secondary metabolites, and synergistic interactions across various pharmacological targets [51]

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