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Clinical, Cosmetic and Investigational Dermatology 2014:7 submit your manuscript | www.dovepress.com Dovepress Dovepress Dovepress 274 Watanabe et al All authors contributed toward data analysis, drafting and revising the paper and agree to be accountable for all aspects of the work

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Figure 4 3.5 The damage of antioxidant enzymes is related to M2 macrophage polarization Real-time quantitative PCR showed that IL-4 promoted M2 macrophage polarization by increasing the mRNA expression of CCL24 and MRC1 ( Figure 5A )

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