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Trials should also incorporate sex-specific analyses, age related stratification, and clinically relevant comorbidities such as gastrointestinal dysfunction and sleep problems, all of which can modulate treatment efficacy

IGF-1 LR3 is a long-acting analogue of insulin-like growth factor 1, engineered with an extended amino acid sequence to reduce binding to IGF-binding proteins, studied within Australian peptide research for its receptor-binding properties

Measurement of plasma AST and ALT activity at end point did not reveal any significant elevation of these markers of liver toxicity in the group of mice treated with -SG diet and PH755 (Supplementary Figure 6d), while plasma urea and creatinine levels remained normal in the double-treated mice, suggesting that there was no kidney damage (Supplementary Figure 6e)

For abdominal fat, rotate through positions around the navel