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ALA is neurotoxic and thought to be the cause of the acute porphyria-like pathology in this TYRSN1

They begin to degranulate chronically, releasing massive amounts of histamine, prostaglandins, and inflammatory cytokines

doi: 10.1016/00166480(84)900765 96 LinSWGeW

However, an imbalance in the number of oxidative molecules due to endogenous or exogenous factors can overwhelm defense systems and lead to excessive production of reactive oxygen species (ROS)