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Shifting Pigment Type (The Eumelanin-to-Pheomelanin Switch) Not all melanin is the same

Understanding the regulation of NRF2 activity and its new emerging functions presents new challenges but also new opportunities for targeting NRF2 in cancer

R., Fletcher, C

Studies indicate that prolonged drug exposure may allow DTP cells sufficient time to acquire permanent genetic alterations, such as secondary resistance mutations or genomic amplifications, transitioning from a reversible adaptive state into irreversible resistance (Dhanyamraju et al., 2022)
Front Immunol (2019) 10:2519
