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Front Immunol 2019;10:2137

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In this regard, it can be noted that transcription of the gdhA gene initiates from two promoters, one weak, constitutively expressed, called gdhA P1, and another, more potent, called gdhA P2, transactivated by GdhR, a transcriptional regulator whose DNA binding is inhibited by -ketoglutarate (Pagliarulo et al., 2004)

This antioxidant not only helps to reduce oxidative stress from various sources but also inhibits melanin synthesis by reducing TYR activity, making it effective for treating hyperpigmentation conditions 171