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They are not approved by the FDA and are not drugs, foods, dietary supplements, or cosmetics

Horvath LG, 2025, 'DARO-LIPID (ANZUP2205): A randomised phase 2 study of sphingosine kinase inhibitor (opaganib) with darolutamide in poor prognostic metastatic castration resistant prostate cancer (mCRPC) based on a circulating lipid biomarker, PCPro', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY , WILEY, pp

Nakano et al

British Journal of Haematology, 62: 712

However, careful consideration of timing and skin sensitivity is crucial