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Both up- and down-regulation of Claudin-7 expressions have been reported in CRCs, and are linked to invasion, metastasis, and disease prognosis 29,30,31,32

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Any potential benefits would likely require integration with dietary modification and physical activity, and neither supplement is recommended in NICE guidance for weight management

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Muscle cramps predominantly afflict the lower limb muscles, notably the calves and feet, though the fingers and hands may also be susceptible (4, 8, 26)

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doi: 10.1517/14740338.2016.1131818

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