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A large number of unmetabolized APAP is metabolized by CYP2E1, resulting in excessive toxic intermediate NAPQI (Torres et al., 2019)

While the precise mechanism of OAT3 in urate transport remains unclear, based on its expression site, it is speculated that it may participate in the uptake of urate in peripheral tubules, contributing to urate secretion, or in moving urate from the basement membrane side into the peritubular capillaries, thus engaging in urate reabsorption (4244)

For three weeks following the treatment period, only sweets and sugar-heavy fruits are restricted

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Blaser, M