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This review differentiates between low-dose methotrexate used in autoimmune diseases and high-dose methotrexate used in oncology, emphasizing mechanistic differences in hepatotoxicity pathways, integrating MASLD-related risk factors, and summarizing current non-invasive diagnostic strategies

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Diabetic rats received insulin (1 IU sc/day), metformin (10 mg/kg/day p.o.) alone, l-carnitine (75 mg/kg/day, i.p.) alone, and a combination of l-carnitine (75 mg/kg/day)+metformin (10 mg/kg/day) daily for 14 days

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