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For example, while HDAC inhibitors reverse ethanol-induced synaptic deficits in mice, their systemic administration in humans risks off-target effects, including gastrointestinal distress and immunosuppression (Arora et al
[PubMed: 25809447] 780
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A separate study using a tendon outgrowth assay reported pro-healing effects of BPC-157 with cell-survival and cell-migration endpoints (Staresinic et al., 2010)
This methylation is crucial to regulate gene expression, neurotransmitter synthesis, myelin formation, and the methylation of histones and DNA (, , )
