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Apart from their broad-spectrum activity, peptides are thermally stable and water-soluble [9,13] and are involved in intracellular angiogenesis (blood vessel formation), inflammation responses, and cell signaling in the host cell [14]

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[95], LL-37 was reported to trigger the production of pro-inflammatory cytokines (IL-1B) by suppressing LPS/ATP-induced macrophages pyroptosis