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First, only male db/db mice were used, which may not capture sex-dependent metabolic responses, as female mice often exhibit different disease progression and therapeutic sensitivity (73)

While IV therapy isn't a cure-all for COVID-19, many patients find it provides meaningful symptom relief and accelerates their recovery process

doi: 10.3389/fphys.2017.00595

This is accompanied by a decrease in OXPHOS that is characterized by blunted TCA cycle and reduced mitochondrial respiration

Therefore, it is evident from the above that molecules having pyrimidine scaffolds have several uses in the development of drugs to treat NDDs [172]