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These factors include potent inflammatory regulators such as Interleukin (IL)-6, Leukemia inhibitory factor (LIF), C-X-C motif chemokine ligand (CXCL)1, CC motif chemokine ligand (CCL)5, and Colony stimulating factor (CSF) 1 [168]

Several studies demonstrate that oral vitamin B12 at a dose of 1000 micrograms daily replaces vitamin B12 levels even for people with pernicious anemia ( Frontiers in Medicine, Aug

(2013) studied serum from 22 FM patients compared with 22 healthy female controls and identified significant alterations in purine metabolism, specifically decreased levels of adenosine, a precursor for ATP synthesis

Vitamins Vitamin B12 is essential for a correct immune function [94]

Other Glutathione-Sparing Compounds Several nutrients help maintain glutathione levels by reducing its consumption or supporting its recycling: Vitamin C (ascorbic acid): Spares glutathione by scavenging reactive oxygen species directly, reducing the demand for glutathione as an antioxidant