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We exploited the secured C-terminal modification site of each peptide, as discussed above, and prepared fluorescently labelled macrocycles aML5-Fluo, aMD4-Fluo and aMD5-Fluo via the -amino group of a lysine residue in a tag peptide at the C-terminus (Supplementary Table 2 and Supplementary Fig

Any disagreements were resolved by consulting other authors

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These factors contribute to the activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome resulting in mitochondrial or cell apoptosis, pyroptosis, a highly pro-inflammatory type of cell death, and stimulation of inflammation [67,177,178]

Overcoming resistance to DNA-targeted agents by epigenetic activation of Schlafen 11 (SLFN11) expression with class I histone deacetylase inhibitors